Significativo aumento de onicomicosis por hongos filamentosos no dermatofitos en red de salud privada en Santiago de Chile entre los períodos 2008-2009 y 2016-2017 / Significant increase in onychomycosis due to Filamentous Fungi Non Dermatophytes in Network of Private Health in Santiago de Chile among the periods 2008-2009 and 2016-2017

INTRODUCCION: La onicomicosis corresponde a una patología prevalente causada por hongos dermatofitos, levaduras y en menor proporción, hongos filamentosos no dermatofitos (HFND). Se ha reportado un aumento a nivel mundial en la incidencia de onicomicosis por HFND1 , sin embargo, en Chile no hay registros de ello. OBJETIVO: Comparar la epidemiología local de onicomicosis por HFND en una red privada de Santiago de Chile entre dos períodos de tiempo. Material y métodos: Se realizó un estudio transversal de análisis de los registros de laboratorio de la Red de Salud UC-Christus entre los períodos 2008- 2009 y 2016-2017. RESULTADOS: Se obtuvieron un total de 9.579 muestras en ambos períodos, 4.985 entre 2008-2009 y 4.594 entre 2016-2017, con 3.442 (36%) cultivos positivos para hongos, 1.831 (36,7%) en el primer período y 1.611 (35%) en el segundo. Del total 40 muestras (1,2%) fueron de HFND, destacando que la prevalencia aumentó significativamente entre ambos períodos: 8 (0,4%) y 32 (2,0%) cultivos, respectivamente (p<0,0001). Del total, las especies de HFND más prevalentes fueron: 23 Fusarium sp (57,5%), 8 Scopulariopsis sp (20%) y 7 Acremonium sp (17,5%). En pacientes con cultivo positivo para HFND, se buscaron asociaciones probables en los antecedentes a través de la ficha clínica, sin encontrar resultados significativos. CONCLUCION: Los HFND son la tercera causa de onicomicosis y su prevalencia fue 1,2%. Las especies más frecuentes fueron Fusarium sp, Scopulariopsis sp, Acremonium sp. La prevalencia de HFND aumentó significativamente en un período de 6 años.

INTRODUCTION: Onychomycosis is a frequent nail disease caused mainly by dermatophytes, in less proportion yeast and last non-dermatophyte molds (NDM). NDM onychomycosis is an increasing problem worldwide, though in Chile there is no epidemiological registry about it. OBJETIVE: The aim of the study was to determine the local epidemiology of NDM onychomycosis. MATERIAL Y METHODS: We did a transversal cohort study in the Red de Salud UC-Christus between 2008-2009 and 2016-2017. RESULTS: Of the 9,579 clinically suspected cases of onychomycosis, 4,985 in 2008-2009 and 4,594 in 2016-2017, 3,448 (36%) cultures were positive in total, 1,831 (36.7%) in the first period and 1,611 (35%) in the second. Only 40 cultures (1.2%) were NDM in total, but the prevalence significantly increased between both periods with 8 (0.45%) and 32 (2.0%) cultures, respectively (p y (p<0.0001). Among the total of NDM, the most prevalent species were: 23 Fusarium sp (57.5%), 8 Scopulariopsis sp (20%) and 7 Acremonium sp (17.5%). We searched for possible associations of patients with NDM onychomycosis and morbid history, but found no significant result. COMCLUSION: NDM are the third cause of onychomycosis and its prevalence of 1.2% was predominantly from toe nails. The most frequent species were Fusarium sp, Scopulariopsis sp. and Acremonium sp. The prevalence of NDM increased significantly in a period of 6 years.

Symplastic hemangioma developing over an infantile hemangioma during propranolol treatment.

We describe a case of a 6-month-old female patient with a segmental, superficial, infantile hemangioma (IH) on the forehead being treated with propranolol 2 mg/kg/d for 5 months, who developed a symplastic hemangioma (SH) over the preexisting lesion, highlighting the need to consider SH in the differential diagnosis of vascular lesions arising over preexisting vascular anomalies in children.

Patrón dermatoscópico en arcoiris (irisado) en dermatofibroma hemosiderótico: reporte de un caso / Dermoscopic pattern in rainbow (iridescent) in hemosiderotic dermatofibroma: a case report

El patrón en arcoiris ha sido un tema controvertido, dado que en un principio se planteó como un patrón dermatoscópico específico asociado al diagnóstico de Sarcoma de Kaposi. Sin embargo, esta asociación ha sido cuestionada por diversos reportes que han evidenciado la presencia de este patrón dermatoscópico en otro tipo de lesiones, tales como, otros tumores vaculares, cicatriz hipertrófica, angioqueratoma, dermatitis por estasis, pseudo-Kaposi (acroangiodermatitis), melanoma, liquen plano, dermatofibroma hemosiderótico, entre otros. Se ha propuesto que este efecto se genera por la absorción, difracción y difusión de la luz polarizada y su interferencia con diferentes componentes vasculares y fibrosos de la dermis más que por algún hallazgo histopatológico específico. Presentamos el primer caso con registro fotográfico de dermatofibroma hemosiderótico con presencia de un 'patrón irisado' en la dermatoscopía.

The dermoscopic 'rainbow pattern' has been a controversial issue; it was initially proposed as a specific dermatoscopic pattern associated with Kaposi's Sarcoma. However, this has been questioned by several reports that have shown the presence of this dermoscopic pattern in a wide variety of lesions such as other vascular tumors, hypertrophic scars, angiokeratoma, stasis dermatitis, pseudo-Kaposi acroandgiodermatitis), melanoma, lichen planus, and hemosiderotic dermatofibroma, among others. It has been proposed that this effect is generated by the absorption, diffraction and diffusion of polarized light and its interference with different vascular and fibrous components of the dermis, rather than being caused by a specific histopathologic finding. We present the first photographically recorded case of hemosiderotic dermatofibroma, characterized by the presence of a rainbow pattern in dermoscopy.

Pseudohypoparathyroidism type 1B associated with assisted reproductive technology.

Evidence suggests an increased incidence of imprinting disorders in children conceived by assisted reproductive technologies (ART). Maternal loss-of-methylation at GNAS exon A/B, observed in pseudohypoparathyroidism type 1b (PHP1B), leads to decreased expression of the stimulatory Gsα. We present a patient conceived by ART, who presented at age 4 years with delayed neurocognitive development and persistently increased creatine kinase (CK). At 6 years an elevated PTH was detected with normal calcium and a low 25(OH) vitamin D level (25OHD). Physical exam showed a narrow forehead, nasal bridge hypoplasia and micropenis. After normalizing vitamin D, PTH remained elevated and PHP1B was therefore considered as the underlying diagnosis. An almost complete loss-of-methylation was observed at GNAS exons A/B and AS, but not at exon XL, which was associated with a gain-of-methylation at exon NESP. There was no evidence of a microdeletion within the GNAS/STX16 region and analysis of several microsatellite markers for the GNAS region on Chr.20q revealed no evidence for paternal uniparental disomy (patUPD20q). Established facts Increased incidence of imprinting disorders in children conceived by assisted reproductive technologies (ART) Pseudohypoparathyroidism is caused by imprinting abnormalities. Novel Insights First report of a possible association between a methylation defects that causes PHP1B and assisted conception Increased creatine kinase level was associated with an increase in PTH concentration.

Estudio Descriptivo: Dosis Efectiva de Radiación en Angiotomografías Coronarias Multidetector de Enero del 2013 a Diciembre del 2015 en el Hospital de Especialidades José Carrasco Arteaga

INTRODUCCIÓN: La coronariografia convencional sigue siendo el patrón de referencia para cuantificar y guiar el tratamiento en la enfermedad coronaria sin embargo con la introducción de la angiotomografía coronaria multidetector en la valoración de placas ateromatosas coronarias y con esto la exposición a la radiación ha permanecido como área de constante preocupación. En la práctica diaria se recomienda basarse en lo que se conoce como As Low As Reasonably Achievable que significa optimizar la radiación sin perjuicio de la calidad del estudio. MÉTODOS: Se trata de un estudio descriptivo retrospectivo en el Hospital de Especialidades José Carrasco Arteaga de Cuenca ­ Ecuador, durante el periodo de tiempo comprendido entre el 01 enero del 2013 y 31 diciembre del 2015. Para este estudio se incluyeron todos los pacientes a quienes se les realizó angiotomografía coronaria multidetector, se recolectaron los datos clínicos y la dosis efectiva de radiación de cada paciente. RESULTADOS: La edad promedio fue de 63.2 años. Con una probabilidad pre-test intermedia-baja para enfermedad coronaria en más del 94 % de los pacientes, de los cuales el promedio de dosis de radiación efectiva en angiotomografía coronaria multidetector es de 13.0276 mSv (0.9002 ­ 20.657).CONCLUSION: Se trata del primer estudio en el medio donde investiga la dosis de radiación utilizada en angiotomografía coronaria multidetector permitiendo conocer la media de dosis efectiva y así optimizar la misma mediante técnicas de reducción.

INTRODUCTION: The conventional coronography continues to be the standard used to quantify and manage the treatment of coronary disease. However, with the introduction of the multidetector coronary angiothomography in the evaluation of coronary atheromatous plaque, the exposure to radiation has continued to be an area of constant concern. It is recommended that in daily practice the As Low as Reasonably Achievable guidelines be used, which means optimizing the amount of radiation without affecting the quality of the study. METHOD: This a descriptive retrospective study that took place at the José Carrasco Arteaga Specialties Hospital in Cuenca ­ Ecuador, covering the time period between January 1, 2013 from December 31, 2015. The clinical data and effective dose of radiation of each patient who underwent a multidetector coronary angiothomography during this time span were included in the study. RESULTS: The average age was 63.2 years, with a low to intermediate pre-test probability of coronary disease in over 94 % of the patients. The average dose of effective radiation in multidetector coronary angiothomography was of 13.0276 mSv (0.9002-20.657). CONCLUSIONS: This is the first study in our area where the dose of radiation used in multidetector coronary angiothomography has been investigated, making it possible to identify the effective half dose, in this way optimizing the same through the use of reduction techniques.

The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility.

Many pharmacological agents have been investigated to manage preterm labor; we postulate that a combination of tocolytic drugs may achieve a better effect in the prevention of uterine contractions without dose-dependent adverse effects. The aim of this study was to evaluate the inhibitory effect of dual combinations of tocolytics in vitro. Human myometrium was obtained during elective cesarean sections (term without labor; n = 40). Myometrial strips were placed in organ baths for the measurement of isometric tension. Contractile activity was induced by oxytocin (10-8 mol/L), then a concentration-response curve to single or dual combinations of tocolytics was started. All studied tocolytics (nifedipine, ritodrine, nitroglycerin, atosiban, and NS-1619), when used alone, significantly inhibited myometrial contractions. When combined, nifedipine plus ritodrine produced a significantly greater inhibition of contractility than each drug alone in the midrange of concentrations. The combination of nifedipine plus nitroglycerin or nifedipine plus atosiban produced a significantly greater inhibition than nitroglycerin or atosiban alone but not greater than nifedipine. The combination of nifedipine plus NS-1619 (Ca+2-activated K+ [BKCa] channel opener) reduced the inhibitory effect of each drug. We concluded that a selected combination of tocolytics (nifedipine plus ritodrine) produced a significantly greater inhibitory effect on contractility than each drug alone at intermediate concentrations. Thus, specific combinations of tocolytics with different intracellular signaling pathways may have a synergic effect constituting a provocative new option for preterm labor treatment.

Impacto del tratamiento no farmacológico de la hipertensión arterial en pacientes de un consultorio médico de la familia / Impact of the non-pharmacological treatment of arterial hypertension in patients from a family doctors office

Se realizó un estudio de intervención, con el objetivo de evaluar el impacto de los cambios en el estilo de vida en pacientes hipertensos, pertenecientes al Consultorio Médico de la Familia 158-01, área de salud del Policlínico Docente Manuel Fajardo Rivero, municipio de Las Tunas, Cuba; durante el período comprendido entre abril de 2013 y diciembre de 2014. El universo estuvo constituido por toda la población dispensarizada con hipertensión arterial esencial y la muestra con los diagnosticados en el Estadio 1, Grupos A y B. Los pacientes se controlaron mensualmente. En un buen número de pacientes el tratamiento no farmacológico fue suficiente para el control de las cifras de presión arterial y en otros se asoció al tratamiento medicamentoso, lo que disminuyó el número de fármacos utilizados. Su cumplimiento fue muy bajo al inicio de la intervención, lo que se revirtió después. Los pacientes que cumplieron estrictamente el tratamiento no farmacológico presentaron mejores controles de las cifras de presión arterial (AU)

An intervention study was carried out with the objective of assessing the impact of lifestyle modifications in hypertensive patients belonging to the family doctors office 158-01 of Manuel Fajardo Rivero Teaching Polyclinic health area in Las Tunas, Cuba, from April, 2013 to December, 2014. The universe was made up of the whole population identified with essential hypertension and the sample included those diagnosed in stage 1, groups A and B. The patients were monitored every month. The non-pharmacological treatment was enough for controlling the blood pressure numbers in a great number of patients; in others, it was associated to the pharmacological treatment, what diminished the number of drugs used. Its accomplishment was very low at the beginning, what was later reverted. Those patients that completed rigorously the non-pharmacological treatment presented a better control of the blood pressure numbers (AU)

Erratum to "growth retardation in children with kidney disease".

[This corrects the article DOI: 10.1155/2013/970946.].

Growth retardation in children with kidney disease.

Growth failure is almost inextricably linked with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Growth failure in CKD has been associated with both increased morbidity and mortality. Growth failure in the setting of kidney disease is multifactorial and is related to poor nutritional status as well as comorbidities, such as anemia, bone and mineral disorders, and alterations in hormonal responses, as well as to aspects of treatment such as steroid exposure. This review covers updated management of growth failure in these children including adequate nutrition, treatment of metabolic alterations, and early administration of recombinant human growth hormone (GH).